重组人白细胞介素-1β, IL-1β

货号:

200-01B

品牌:

Peprotech

规格:

20µg

概述

Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

研究领域:

细胞生物学

详述

IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

氨基酸序列:

APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

来源:

E.coli

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 10⁹ units/mg.

交叉反应:

Frog, Monkey, Mouse, Rabbit, Rat, Sheep, Human, Mouse + Chicken, Cow, Human + Rat, Pig

储存与安全

储存:

2℃~8℃

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重组人白细胞介素-1β, IL-1β